Services

In collaboration with Fox Chase Cancer Center we have initiated a program focused on development of PDX models in various cancer indications. These indications include pancreatic, renal, esophageal, gastric, colon, rectal, breast, lung carcinomas, lymphoma and many others. For all our established models patient information including stage/grade, age, gender, race and tumor growth curves are available. For most of these tumor models we also have information on adjuvant and neo-adjuvant treatments and patients responses. All initial specimens in our model collection have been developed predominantly from patients with Caucasian ethnicity.

Most of the models have accompanied with Whole Exome Sequence and RNA Seq data, oncogene panel sequences and microarray analysis of gene expression as well as some limited information on xeno-trials in mice. We will be more than happy to discuss a possibility to share with you our models on non-exclusive basis. In addition, since we have a broad IRB protocol with Fox Chase Cancer Center, that allow us to implant any type of tumors we would be happy to offer you to implant models that are of particular interest for you. Fox Chase Cancer Center is one of the largest and oldest oncological institutions in US and it provides care for all type of oncological patients except pediatric cancers and brain cancers.

Procedure

  • SOP 1

    BRF identifies and consents the patient prior to surgery

  • SOP 2

    BRF delivers a slip and transport vial

  • SOP 3

    Freshly obtained tumor sample placed in media

  • SOP 4

    Pathology

    • BRF number assigned

    • If not placed in the OR, a sterile 1cm3 tumor sample within 20 minutes in cold transport media

    • Pathologist releases the BRF sample if deemed “residual” from clincial care

  • SOP 5
    SOP 5
    SOP 5

    BioSample Repository

    Provides sample for PDX implantation

    Tumor tissue Processed

    • Paraffin fixed

    • Frozen

    • Tumor and blood DNA

    Clinical Information