Cancer is the second leading cause of death in the United States, and there is a continuing need to provide new, safer cancer drugs to patients. We at NexusPharma are actively pursuing this unmet need to provide effective discovery tools to select novel therapeutics with fewer side effects for cancer patients. Together with Fox Chase Cancer Center, a co-founder of the company, we are dedicated to developing patient-derived tumor disease models to advance the discovery of effective drugs.

What began in 2005 in the research and clinical laboratories of Fox Chase Cancer Center to support better patient treatment has resulted in a panel of patient-derived xenograft (PDX) models to validate the biological activity of cancer treatment compounds.

These technologies have become the cornerstone for creating a pipeline of novel PDX models as more predictive drug discovery tools. NexusPharma characterizes its PDX models by genomic analysis, such as mRNA sequencing to unravel critical cancer signaling networks. In addition, genetic profile sequencing is validated using orthogonal quantitative methods.

NexusPharma is developing a database of compounds and their activities in various PDX or PDX derived cell lines. Together, using information about tumor model genetics, we are building a predictive correlation between biological targets and compound efficacy.

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NexusPharma is a member of Genesis Drug Discovery and Development (GD3) the contract research organization (CRO) of Genesis Biotechnology Group® (GBG). GD3 is a preclinical Contract Research Organization which offers an integrated portfolio of drug discovery services from target validation and assay development to advancing compounds from “hit to lead” to “lead optimization”. GD3’s members include:

  • Venenum Biodesign

    Venenum Biodesigns is composed of biologists and chemists with years of experience identifying validated small molecule drug targets across therapeutic areas. Once validated, we develop state-of-the-art assays and models for HTS or Rational design.

  • Invivotek

    Invivotek is focused on custom and standard in vivo drug testing services and phenotypic characterization of genetically modified rodents to support drug discovery and development programs of clients.

  • PharmOptima

    PharmOptima’s in vivo services include studies in the fields of drug absorption, distribution, metabolism, excretion, and pharmacokinetics (ADME/PK). PharmOptima provides liquid chromatography and mass spectrometry (LC-MS/MS) bioanalysis in support of discovery and development programs, including method development and validation in accordance with regulatory guidelines

  • NEDP

  • Comparative Biosciences Inc

  • Ingenio Diagnostics

  • Statking

  • Integrated Aanalytical Solutions

  • BioBlocks